AIDS. 31(17):2431–2433, NOVEMBER 13, 2017

DOI: 10.1097/QAD.0000000000001661

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PMID: 29028655

Issn Print: 0269-9370

Publication Date: November 13, 2017


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Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Cheila Rocha;Joana Duarte;Pedro Borrego;Rita Calado;José Marcelino;Rita Tendeiro;Emília Valadas;Ana Sousa;Nuno Taveira;

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Abstract

Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

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