Functional Magnetic Resonance and Spectroscopy in Drug and Substance Abuse


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Abstract

Objectives:Functional magnetic resonance imaging (fMRI) and proton magnetic resonance spectroscopy (1H-MRS) were utilized to evaluate functional and metabolic brain changes in drug abusers.Methods:Functional neuroimaging studies in alcohol, cocaine, cigarette, and cannabis abusers were reviewed in the medical literature from 2000 to 2005.Results:Brain activation with functional magnetic resonance imaging is different in drug abusers and may show more or less activation according to the task and gender. Lower concentrations of N-acetylaspartate and higher creatine are usually seen with 1H-MRS in the brains of cigarette smokers, people who are cocaine dependent, and alcohol abusers.Conclusions:Neural substrates of drug addition, craving, drug interaction, individual abstinence, and drug withdrawal can be studied with functional magnetic resonance imaging and proton magnetic resonance spectroscopy.

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