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The use of imaging in the evaluation of the brain under the influence of drugs has evolved into a functional assessment of its processes. It has been shown that SPECT and PET imaging studies demonstrate selected areas that are affected by multiple drugs among substance abusers. This paper illustrates examples of different drugs and how their effect on the brain may be portrayed by imaging applications. The developing “road maps” that we have obtained possess multidimensional applications. They can be useful to confirm specific diseases, clarify diagnosis wherein the clinical picture is not observed, aid in the development of new treatment evaluations and also provide researchers a better insight in the detection and functionality of dementia and specific mental illnesses processes.