Henoch–Schönlein purpura


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Abstract

Purpose of reviewTo provide an update on recent advances in the genetic susceptibility, pathogenesis and treatment of Henoch–Schönlein purpura.Recent findingsRecent work has advanced our understanding of the genetic susceptibility and pathogenesis of Henoch–Schönlein purpura, but there are still significant gaps in our knowledge. Information concerning the most effective treatment of Henoch–Schönlein purpura has begun to emerge. Corticosteroid therapy reduces the duration and severity of abdominal and joint pain, but corticosteroids do not prevent the development of nephritis, or alter the natural history of Henoch–Schönlein purpura. The most effective treatment for severe nephritis remains unclear despite multiple, mostly retrospective reports investigating a variety of drugs.SummaryDespite recent progress, our understanding of the genetic susceptibility, pathogenesis and treatment of Henoch–Schönlein purpura remains incomplete. Further research is necessary in order to clearly define the genetic susceptibility and the pathogenesis of Henoch–Schönlein purpura. Multicenter clinical trials are needed to determine the most effective treatment of Henoch–Schönlein purpura, particularly for patients with severe nephritis.

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