aCenter for Data Sciences, Brigham and Women's HospitalbDivision of Genetics, Brigham and Women's Hospital and Harvard Medical School, BostoncProgram in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute and Harvard University, CambridgedDepartment of Biomedical Informatics, Harvard Medical SchooleDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USAfFaculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom