Ophthalmic Plastic & Reconstructive Surgery. 27(4):e87-e88, JUL 2011

DOI: 10.1097/IOP.0b013e3181ef72a1

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PMID: 21242854

Issn Print: 0740-9303

Publication Date: 2011/07/01


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Drug-Induced Graves Disease From CTLA-4 Receptor Suppression

Gary Borodic;David M. Hinkle;Yihong Cia;

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Abstract

Monoclonal antibody, ipilimumab, useful for treatment of metastatic melanoma, blocks CTLA-4 mediated T-cell suppression and can also cause a Graves ophthalmopathy like syndrome. Epidemiologic study has linked variant polymorphisms of CTLA-4 receptor gene to the presence of thyroid eye disease. The combination of these observations suggests CTLA-4 mediated T-cell functions are important to the pathogenesis of thyroid-associated eye disease.

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