Issn Print: 1058-2916

Publication Date: 2001/03/01


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UNIVENTRICULAR “HEART PATCH” DIRECT CARDIAC COMPRESSION (DCC): HEMODYNAMIC EFFECT IN AWAKE ACUTE HEART FAILURE (HF) SHEEP

Y Huang; S Plekhanov; W Seare; T Nishimura; I Ramanathan; P Brady; S. Hunyor

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Excerpt

Heart Patch DCC, when used in a biventricular configuration, has bee effective in other studies in reversing the hemodynamic abnormality in acute HF sheep. While capacity for biventricular assist broadens the applicability of this device we also wanted to test if isolated LV support was effective. A single ventricle support device would lead to significant savings in terms of intrathoracic “real estate”.
Three sheep (48 ± 8 Kg) were implanted under anesthesia with one Hear Patch on each of the LV and RV free walls. A flow probe on the ascendin aorta measured cardiac output (CO) while carotid artery and jugular vei catheters were used for BP monitoring and drug infusion. Two weeks later, IV esmolol 1.67 (0.96 to 4.77)g was infused to induce a stable 50% reduction of stroke volume (SV). A driving pressure of 191±19 mmHg an assist duration of 160–240ms was used to activate only the LV patch with 1:1 synchronization to the heart beat (DCC-L on). The optima hemodynamic effect and response to cessation of DCC assist (DCC off) is shown in the Table.
Univentricular (LV) activation of the Heart Patch DCC device was able to effectively restore hemodynamic parameters in awake sheep after induction af acute heart failure.

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