Issn Print: 1058-2916

Publication Date: 2002/03/01


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LDL APHRESIS MAY BE BENEFICIAL FOR ACUTE CORONARY SYNDROME

Yasunori Kutsumi; Nobuyoshi Tanaka; Masayuki Kato; Hideaki Okaraki

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Author Information: Division of Cardiology, The Fukui Chuoh Clinic.

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Excerpt

(Background and purpose) Increased high sensitive C-reactive protein (hsCRP) has been proven as a risk predictor for cornary arterial disease. LDL apheresis reduces not only LDL cholesterol, but also hsCRP. The purpose of the present study was to clarify the clinical effect of LDL apheresis on patients with acute coronary syndrome.
(Clinical study) We investigated the clinical effect of apheresis on six patients with acute coronary syndrome who were excluded from both percutaneous coronary intervention and surgery. Four patients (L-group) underwent LDL apheresis on alternate days for one week using conventional therapy. Two patients IC-group) did not undergo LDL apheresis because we did not receive their informed consent to go so. The levels of hsCRP, LDL cholesterol, fibrinogen decreased significantly in the L-group. Pre-and post one week treatment of LDL cholesterol levels were 214 ±32mg/dl and 134±24mg/dl; hsCRP were 2.34 ± 1.02mg/ml and 0.58±0.24mg/ml; fibrinogen levels were 268±36mg/dl and 114±95mg/dl. However, there were no significant changes in these parameters in the C-group. Subjective symptoms in the L-group were improved markedly. There were no cardiac events in the L-group. One patient in the C-group suffered a myocardial infarction.
(Conclusion) This preliminary study indicates that LDL apheresis may have beneficial effects on acute coronary syndrome.

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