Methylphenidate-Induced Psychosis in Adult Attention-Deficit/Hyperactivity Disorder: Report of 3 New Cases and Review of the Literature

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Abstract

Objective:

We present 3 new cases of psychotic symptoms in patients with adult attention-deficit/hyperactivity disorder while regularly treated with a stimulant therapy with methylphenidate.

Methods:

Existing literature about this theme is reviewed, and potential mechanisms are discussed.

Results and Conclusions:

Medication with methylphenidate should be avoided in patients with vulnerability to schizophrenia and in drug addiction, but reported cases without these risk factors demonstrate that a careful and regular psychiatric monitoring is essential in all patients treated with methylphenidate.

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