Four patients with non-pulmonary soft tissue metastases of osteosarcoma are presented. These lesions were readily demonstrated on 99mTc bone scans. Calcification was evident radiographically in all of the non-pulmonary lesions. In one instance, the recurrence would have been missed without the bone scan, and in another the bone scan first suggested the diagnosis. Bone scans have proven useful in the initial evaluation of osteosarcoma and in monitoring the results of therapy.