Issn Print: 0363-9762
Publication Date: 1998/07/01
F-18 DEOXYGLUCOSE (FDG) AND TC-99M-MDP SIMULTANEOUS WHOLE BODY SPECT IMAGING IN THE DETECTION AND LOCALIZATION OF TUMORS.
; G A Francken; C C Chau; H G Gabbie; B B Woods; D R Chapman
Excerpt
Modified Anger cameras are currently capable of performing high energy FDG SPECT studies often detecting sub centimeter tumors with high target to background ratios. Anatomic localization of these foci are often difficult without the traditional landmarks present on bone or gallium studies. The purpose of the current study was to determine if dual isotope imaging using Tc-99m-MDP or GA 67 will be helpful in further clarifying the results of FDG SPECT. 20 patients were studied using FDG whole body SPECT techniques with a modified dual detector Anger camera with an elongated field of view and simultaneous dual peak acquisition capability. 15 patients underwent simultaneous FDG/Tc-99m-MDP imaging while 5 patients underwent simultaneous FDG/GA67 imaging. In 10 of the 15 patients undergoing simultaneous FDG/MDP studies simultaneous imaging with composite registration was critical in determining the nature of the lesion (osseous vs. soft tissue) or location. In 4 of the 5 simultaneous FDG/GA67 studies localization was enhanced. Additionally, abnormalities noted on bone SPECT often were negative on FDG and proved to be degenerative and/or compressive abnormalities validated by other imaging techniques. In conclusion, simultaneous FDG/Tc-99m-MDP imaging proved valuable in over 2/3 of the patients studied with respect to lesion localization and characterizing the nature of abnormality. It is recommended that FDG SPECT be accompanied by dual isotope imaging when feasible.
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