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Sarcoidosis is a chronic systemic inflammatory disease of unknown origin preferentially involving the lungs with associated hilar and mediastinal adenopathy. Characteristic radiologic and PET features of thoracic sarcoidosis are well recognized by clinicians and imagers. Disseminated and extrathoracic sarcoid lesions targeting bones, breast, liver, and abdominal and pelvic nodes may mimic widespread high metabolic metastases or diffuse lymphomatous disease on F-18 FDG PET imaging. The author presents such an uncommon multisystemic sarcoid distribution with scintigraphic demonstration of breast involvement and large confluent hepatic lesions simulating advanced malignancy.