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Isolated colonic schwannomas are rare gastrointestinal mesenchymal tumors; only a small number of cases have been reported. The incidence is 2% to 6% of all submucosal tumors of the gastrointestinal tract. They are thought to be distinctive from conventional schwannomas that arise in soft tissue or the central nervous system. Although colonic schwannomas are considered benign, these lesions may demonstrate intense FDG avidity, which makes them indistinguishable from the more common potentially malignant gastrointestinal stromal tumor.