<i>progesterone Receptors: Expression and Regulation in the Mammalian Ovary</i>

Issn Print: 0009-9201

Publication Date: 1996/06/01

Progesterone Receptors: Expression and Regulation in the Mammalian Ovary

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Excerpt

The reproductive cycle of female mammals is regulated by feedback and feedforward hormonal interactions at the hypothalamic-pituitary-ovarian axis. One of the major hormonal regulators is the ovarian steroid progesterone. Progesterone is synthesized and secreted by ovarian follicles at different stages under the control of the pituitary gonadotropins luteinizing hormone and follicle-stimulating hormone, and it exerts profound effects on the growth, development, and differentiation of many reproductive tissues including the brain, pituitary, uterus, mammary gland, and ovary. In addition, progesterone can modulate proliferation and differentiation of transformed cells, such as breast cancer cells. All of these tissues contain intracellularly located receptors that transduce the biologic activity of progesterone to the genome.1 In this article, we will briefly discuss the structure, function, expression, and regulation of progesterone receptors (PRs) in the mammalian ovary.


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