Issn Print: 0009-9201
Publication Date: 2001/03/01
Management of Antiphospholipid Syndrome During Pregnancy
Excerpt
Since it was first described a quarter of a century ago, antiphospholipid syndrome (APS) has been associated with multiple medical and obstetric complications. Antiphospholipid syndrome is defined by characteristic clinical features and the presence of circulating antiphospholipid antibodies (aPL). Although several antiphospholipid antibodies have been described, the two most clinically useful are the lupus anticoagulant (LA) and anticardiolipin antibodies (aCL), which have been associated with recurrent pregnancy loss and thromboembolism. 1–4 Antiphospholipid syndrome pregnancies resulting in surviving infants are often complicated by fetal growth impairment, preeclampsia, placental insufficiency, and preterm birth. 5,6 Appropriate treatment of APS during pregnancy, however, may significantly improve both maternal and neonatal outcomes. This review outlines management plans for pregnancies complicated by APS.
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