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To evaluate agreement between IOP measured using the ocular response analyzer (ORA) versus using the Goldmann applanation tonometer (GAT) in patients treated by Descemet stripping automated endothelial keratoplasty (DSAEK).This prospective, case–control study comprised 38 normal eyes and 37 post-DSAEK eyes. IOP was measured using the GAT (IOPGAT). The ORA was used to measure corneal biomechanics and cornea-compensated IOP (IOPCC). Corneal hysteresis (CH), corneal resistance factor, and IOP measurements of the 2 groups were compared. Intertonometer agreement was evaluated in each study group using Bland–Altman plots and 95% limits of agreement. Univariate analysis was used to evaluate the effect of independent factors on the difference between the 2 IOP readings (ΔIOP).The IOPCC and IOPGAT readings showed no significant intergroup differences. IOPCC was significantly higher than IOPGAT, with a mean difference of 3.0 ± 3.3 mm Hg in the normal group (P < 0.001) and 4.5 ± 3.1 mm Hg in the DSAEK group (P < 0.001). The 95% limits of agreement for the IOPCC and IOPGAT was between −3.4 and 9.5 mm Hg and between −1.6 and 10.6 mm Hg in the normal and DSAEK groups, respectively. CH (r = −0.57, P < 0.001) and donor thickness (r = 0.81, P = 0.04) were identified as the main predictors of ΔIOP after DSAEK. ΔIOP did not vary significantly with the central corneal thickness or corneal resistance factor.The IOPGAT and IOPCC were significantly different, which indicates that the GAT and ORA cannot be used interchangeably for measuring IOP after DSAEK. The difference between these 2 measurements was primarily affected by the variations in CH and donor thickness.