Evolving antimicrobial chemotherapy for Staphylococcus aureus infections: Our backs to the wall

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Staphylococcus aureus is responsible for many nosocomial and community-acquired infections. Its evolving resistance to traditional antimicrobial chemotherapy and emerging prevalence outside of the healthcare environment are serious concerns. This review of the changing epidemiology of methicillin-resistant S. aureus, the emergence of vancomycin (glycopeptide)-resistant isolates, and the mechanisms of resistance to β-lactams and glycopeptides provides an update for clinicians regarding effective strategies for treatment.

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