To synthesize the emerging body of experimental, observational, and clinical trial data into a practical guideline for safe and effective ventilatory management of acute respiratory distress syndrome.Data Sources
Relevant, peer-reviewed, scientific literature and personal observations from clinical practice.Study Selection
Relevant experimental studies and high-impact observational and clinical trials of acute respiratory distress syndrome management.Data Extraction
Detailed review of information contained in published scientific work.Data Synthesis
Interactive discussions between the authors that culminated in our consensus view of appropriate management.Conclusions
Prevention of ventilator-induced lung injury while accomplishing the essential life-supporting roles of mechanical ventilation is a complex undertaking that requires application of principles founded on a broad experimental and clinical database and on the results of well-executed clinical trials. At the bedside, execution of an effective lung-protective ventilation strategy remains an empirical process best guided by integrated physiology and a readiness to revise the management approach depending on the individual’s response.