Reduced Expression Of Scavenger Receptor On Alveolar Macrophages From Sp-a Deficient Mice: 476

Ann Marie Levine; Thomas Korfhagen

Issn Print: 0090-3493

Publication Date: 2004/12/01

REDUCED EXPRESSION OF SCAVENGER RECEPTOR ON ALVEOLAR MACROPHAGES FROM SP-A DEFICIENT MICE: 476

Ann Marie LeVine; Thomas Korfhagen


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Excerpt

Surfactant protein-A (SP-A), a member of the Ca-dependent lectin family expressed in the lung, enhances uptake of various bacteria by alveolar macrophages in vitro and in vivo. Alveolar macrophages from SP-A gene inactivated mice (SP-A−/−) phagocytose bacteria less efficiently than wild type macrophages. Class A scavenger receptors (SR) bind and mediate phagocytosis of bacteria.


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