Issn Print: 0090-3493
Publication Date: 2006/12/01
INTERFERONS (IFNS) PROLONG LPS ACTIVATION OF THE NFκB PATHWAY.: 134
Lesley Doughty; Vivian Wolfe; Basilia Zingarelli; Hector Wong
Excerpt
Many antecedent, clinically mild, viral infections can predispose the host to subsequent severe bacterial infections resulting in significant morbidity and mortality. IFNαand IFNγare induced during most viral infections and can potentiate LPS- induced cytokine production and lethality in animal models. The mechanisms by which antiviral cytokines modulate hyper- responsiveness to LPS are unclear. We examined the impact of IFNs on key LPS signaling molecules including TLR-4/MD-2 expression and elements of the NFκB pathway.
Facebook
Twitter
LinkedIn
Email
