logo

Is Early Goal-Directed Therapy Harmful to Patients With Sepsis and High Disease Severity?

    loading  Checking for direct PDF access through Ovid

Excerpt

A protocol for resuscitation known as “early goal-directed therapy” (EGDT) has been promulgated since 2001 when Rivers et al (1) showed survival benefits in patients with severe sepsis and septic shock. Many observational and quasi-experimental studies have found similar results. Recently, three large randomized trials could not confirm a survival advantage using this approach. A just-published individual patient data meta-analysis performed as a collaboration among the authors of the three randomized trials confirmed that EGDT did not result in better outcomes compared with usual care (2).

Related Topics

    loading  Loading Related Articles

Join Ovid Insights!

Benefits of Ovid Insights Include:

  • Consolidated email digests of the latest research in your favorite topics
  • A personalized dashboard of your topics all on one page 
  • Tools to bookmark and share articles of interest
  • Ability to customize and save your own searches

Register with Ovid Insights »