Follow-Up After Curative Resection of Colorectal Cancer: A Meta-Analysis

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This is a systematic review to evaluate the impact of various follow-up intensities and strategies on the outcome of patients after curative surgery for colorectal cancer.


All randomized trials up to January 2007, comparing different follow-up intensities and strategies, were retrieved. Meta-analysis was performed by using the Forest plot review.


Eight randomized, clinical trials with 2,923 patients with colorectal cancer undergoing curative resection were reviewed. There was a significant reduction in overall mortality in patients having intensive follow-up (intensivevs.less intensive follow-up: 21.8vs. 25.7 percent;P= 0.01). Regular surveillance with serum carcinoembryonic antigen (P= 0.0002) and colonoscopy (P= 0.04) demonstrated a significant impact on overall mortality. However, cancer-related mortality did not show any significant difference. There was no significant difference in all-site recurrence and in local or distant metastasis. Detection of isolated local and hepatic recurrences was similar. Intensive follow-up detected asymptomatic recurrence more frequently (18.9vs.6.3 percent;P< 0.00001) and 5.91 months earlier than less intensive follow-up protocol; these were demonstrated with all investigation strategies used. Intensive surveillance program detected recurrences that were significantly more amenable to surgical reresection (10.7vs.5.7 percent;P= 0.0002). The chance of curative reresection were significantly better with more intensive follow-up (24.3vs.9.9 percent;P= 0.0001), independent of the investigation strategies used.


Intensive follow-up after curative resection of colorectal cancer improved overall survival and reresection rate for recurrent disease. However, the cancer-related mortality was not improved and the survival benefit was not related to earlier detection and treatment of recurrent disease.

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