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Introduction: The mortality rate of ICU surgical patients with dignosed peritonitis remains high because of infection, despite of the use of newer antibiotics and improved supportive treatment. The aim of this study was to investigate the effects of Sandoglobulin on the survival of these patients.
Methods: We studied 51 patients who had undergone emergency surgery due to peritonitis and pyeloperitonitis, with sepsis score <14. Initially they received the same antibiotic regimen and supportive treatment. The patients were randomly allocated in two groups. Group I (n = 21) received human albumin continously infused to a total dose of 8 mL kg−1 for 3 days. Group II (n = 30) received Sandoglobulin in a total dose of 1 mg kg−1 for the same period. We studied outcome, duration of stay in ICU, development of pneumonia, septic shock and multiple organ failure. ANOVA and χ2 test were used for data analysis, and P<0.05 was regarded as significant.
Results: No statistical differences were found between the two groups in the initial sepsis, APACHE score, number of transfused units of blood and plasma. The outcome of the treatment is presented in the table.
Conclusion: It appears that the i.v. administration of Sandoglobulin to ICU surgical patients with severe sepsis reduces the risk of postoperative infections, improves outcome and decreases mortality significantly.
