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Excerpt
Background and goal of study: After administration of a fat emulsion (FE) changes in the plasma levels of the arachidonic acid (AA) vasoactive metabolites are to be expected. The goal of this study was to define the relationship between the prostacyclin/thromboxane A2 levels and the general lung function.
Materials and methods: In eight patients blood for analysis of prostanoids was sampled following the administration of normal saline (NS), FE and diffuse lung capacity for CO (DLCO) was measured. The FE was administered at the rates of 9.1 g kg−1 h−1, 0.2 g kg−1 h−1 and as a bolus of 0.1 g kg−2 min−1. The results of the measurements are expressed as the means ± standard deviations. The ANOVA was used for statistical evaluation.
Results and discussion: The Table shows the changes in the prostanoid plasma levels and DLCO depending on the rate of the FE administration.
If FE is infused (1) at a rate of 0.1 g/kg/h, the prostacyclin level shows a statistically significant increase compared to that found for the NS administration (2) at a rate of 0.2 g kg h, the thromboxane to prostacyclin ratio rises (statistically insignificantly) compared to the NS, while the DLCO shows a statistically significant decrease (3) as a bolus of 0.1 g kg−2 min−1, the thromboxane level and the thromboxane to prostacyclin ratio increase statistically significantly compared to those found for the NS administration, while the DLCO shows a statically significant decrease.
Conclusion: The IV administration of the FE into the central venous blood-stream may significantly influence the endogenous production of prostanoids. The effect of the FE administration and the resulting higher level of prostacyclin on pulmonary hypertension is the subject of further study.
