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Materials and Methods: After approval by the local ethic committee and informed consent 46 patients (pat) were randomized in 2 groups (gr): Mo gr. and Saline (Sal; placebo) gr. Anaesthesia was induced with fentanyl 2 μg/kg, propofol 2mg/kg, atracurium and maintained with remifentanil 0.25-0.5 μg/kg/min and isoflurane 0.5 MAC. At the end of surgery Mo 0.4 mg or Sal was administered intrathecally under vision by the surgeon. Blood samples for blood gas analyses were obtained. VAS scores for pain at rest were assessed before surgery and 4h, 8h, 12h, 16h and 20 h after surgery. PCA-Piritramide (a synthetic opioid) consumption was recorded during the observation period. Stat: Mann-Whitney.
Results and Discussions: Demographic and surgical data were comparable between groups (n.s.). There was no significant difference in side effects and complications after surgery (n.s.). Blood gas analyses were comparable (n.s.). VAS scores for pain before surgery (baseline) were comparable between the groups (n.s.). However, after surgery the VAS scores were significantly decreased in the Mo gr compared with the Sal gr: 20 ± 24 vs. 33 ± 19 (at 4h), 16 ± 22 vs. 28 ± 16 (at 8h) respectively; p < 0.05. Moreover, cumulative piritramide consumption was significantly lower in the Mo gr: 20mg vs. 34 mg (Sal gr), respectively, p < 0.05.
Conclusions: Intrathecal Mo significantly decreased pain intensity and supplementary oipioid consumption after spine surgery. In addition, it is not associated with clinically significant side effects or complications.
