Issn Print: 0265-0215

Publication Date: 2006/06/01


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Comparison between two regimens for general anesthesia in gynecological surgery using auditory evoked potentials (AEPs): A-543

I. Smilov; D. Uzunova

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Author Information: Department of Anesthesiology, University Hospital of Obstetric and Gynecology, Sofia, Bulgaria; 2Department of Anesthesiology, University Hospital of Obstetric and Gynecology

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Background and Goals: Monitoring the mid-latency auditory evoked potentials (AEPs) has been proposed as a measure to ascertain the adequacy of the hypnotic state during surgery. The study aimed to compare the costs of Propofol (Astra-Zeneca) versus Sevoflurane (Abbott Laboratories) for the maintenance of anaesthesia guided by AEPs for gynaecological operations.
Material and Methods: After institutional approval 20 ASA I class patients, undergoing elective gynaecological operations, were randomized in two groups, similar in age, weight, type and duration of operations. All patients received the same induction of anaesthesia. In the Group I (n = 10) anaesthesia maintenance was made by propofol in the dose regimen adapted according to AEPs, (latency of the wave Nb: 60-70 ms; Datex-Ohmeda AS/3, Module M-EEG/EP), fentanyl 3-5mkg/kg and pipecoronium 0.08-0.1 mg/kg. In group II (n = 10) anaesthesia maintenance was with sevoflurane in inspiratory concentrations adjusted by AEPs, (latency of the wave Nb: 60-70 ms; Datex-Ohmeda AS/3, Module M-EEG/EP) in fresh gas flow - 3 l/min (O2/air - 2:1), fentanyl 3-5mkg/kg and pipecoronium 0.08-0.1 mg/kg.
The statistical analysis was performed by ANOVA.
Results and Conclusions: The good quality of anaesthesia was achieved in all studied patients. The recovery was fast and smooth. Score of Aldrete & Kroulik was 9.8 and 9.7 for group I and II, respectively.
In group I - 6.5mg/kg/h propofol and in group II - 0.2ml/kg/h liquid sevoflurane were used for maintenance. The cost of maintenance was higher when using propofol (35.4 Iv.) than sevoflurane (26.9 Iv.) (p < 0.05). According to the interview of the patients for both groups, 24 hours after the surgery, there were not data of awareness and memories which might be connected with the events during operation.
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