Issn Print: 0265-0215

Publication Date: 2007/06/01


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Diabetes inhibits coronary collateral development in a canine model of repetitive coronary occlusion: 4AP9-4

W. Gu; B. Yu; J. Tessmer; D. Warltier; J. Kersten

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Excerpt

Background and Goal: Diabetic individuals with acute coronary syndrome have an increased risk of adverse cardiovascular events (1). Recent studies demonstrated that a well-developed collateral circulation is associated with higher survival rate, smaller infarct size as compared to poor collaterals (2). We tested the hypothesis that diabetes inhibits the coronary collateral development in a canine model of repetitive coronary occlusion.
Materials and Methods: Dogs were subjected to brief (2 min), repetitive coronary artery occlusions (1/h, 8/day, 21day duration) in the absence (control) or presence of diabetes (diabetes). A sham group was instrumented identically but received no occlusion. Myocardial blood flow was determined in the myocardium perfused by the LAD and the LCCA. Peak reactive hyperemia response (PRH) was recorded. Collateral blood flow was expressed as the percentage of normal zone blood flow.
Results and Discussions: Coronary collateral blood flow was shown in the figure. PRH in the control group was significantly lower than that on day 1. PRH remained unchanged in the diabetes and the sham group.
Conclusion(s): Diabetes inhibits the development of coronary collateral blood flow.
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