Issn Print: 0265-0215

Publication Date: 2007/06/01


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Stress measured by biopyrrin, an oxidative substance of bilirubin, in two groups who underwent different neurosurgical procedures: 7AP4-2

H. Dohgomori; S. Nagata; R. Kanemaru; A. Kawanishi; K. Tanioka

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Background and Goal of Study: Urine biopyrrin (BYP) reveals the degrees of oxidant stress and various kinds of stress. The purpose in the present study was to evaluate the stress between two groups of patients who underwent different neurosurgical procedures by measuring BYP values.
Patients and Methods: After obtaining institutional approval and informed consent, 15 patients were enrolled in the present study. Patients were divided into two groups: patients who underwent cranial surgical procedures (G-A) and those who underwent interventional radiology (IVR) to treat their cranial diseases (G-B). BYP values were measured three times in each patient: 1) on the morning before surgery (T-1); 2) the first postoperative day (T-2); and 3) the third or fourth postoperative day (T-3). The urine samples were frozen and measured later, using the Biopyrrin EIA Kit produced by Shino-test Ltd. Urine creatinine was measured at the same time. The BYP data (micromol/gCre) were calculated as the BYP values divided by the urine creatinine values. All values were expressed as means. Statistical analysis was performed using repeated measurements analysis (ANOVA) with Scheff's test.
Results and Discussion: In G-A, nine patients (6 males) were enrolled with a mean age of 63.9 yr (range 39-74 yr). Six patients formed the G-B group (5 males), with a mean age of 72.9 yr (range 55-78 yr). BYP values at times T1, T2 and T3 were as follows for groups A and B, respectively: 3.1, 6.2, 5.4 (P = 0.02); and 3.1, 4.2, 3.8 (P = 0.195). There was no significant difference between the two groups (P = 0.06). Biopyrrin is formed from the oxidation of bilirubin. It reveals the cascade condition of the bilirubin metabolism. Some studies reported that it also revealed the degree of stressed condition and increased even with surgical stress. Generally, craniotomy is thought to be more a more invasive and stressful procedure compared with less invasive surgical maneuvers, such as IVR. In the study, we could not find any difference between the two groups, but a change was noted in more stressful G-A subjects.
Conclusions: BYP levels might reveal different levels of surgical stress and be useful in evaluating various kinds of surgical stress. Further studies are warranted.
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