Excitation-Contraction Uncoupling: Major Role in Contraction-Induced Muscle Injury

Abstract

WARREN, G.L., C.P. INGALLS, D.A. LOWE, and R.B. ARMSTRONG. Excitation-contraction uncoupling: major role in contraction-induced muscle injury. Exerc. Sports Sci. Rev., Vol. 29, No. 2, pp. 82-87, 2001. The mechanisms that account for the strength loss after contraction-induced muscle injury remain controversial. We present data showing that (1) most of the early strength loss results from a failure of excitation-contraction coupling and (2) a slow loss of contractile protein in the days after injury prolongs the recovery time.