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MONTAIN, S.J., M.N. SAWKA, and C.B. WENGER. Hyponatremia associated with exercise: risk factors and pathogenesis. Exerc. Sports Sci. Rev., Vol. 29, No. 3, pp. 113–117, 2001. Exercise-related hyponatremia is an infrequent but potentially life-threatening accompaniment of prolonged exercise. This condition results from sodium losses in sweat, excessive water intake, or both. We review the risk factors for development of this condition and discuss evidence that there is a population at increased risk of hyponatremia during prolonged exercise.