Exercise and Sport Sciences Reviews. 45(2):80–86, APRIL 2017

DOI: 10.1249/JES.0000000000000106

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PMID: 28118158

Issn Print: 0091-6331

Publication Date: April 2017


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Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms

Sophie Carter;Yvonne Hartman;Sophie Holder;Dick Thijssen;Nicola Hopkins;

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Abstract

Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which may be independent of physical activity. To date, the mechanism(s) that mediate this relationship are poorly understood. We hypothesize that sedentary behavior modifies key hemodynamic, inflammatory, and metabolic processes resulting in impaired arterial health. Subsequently, these vascular impairments directly and indirectly contribute to the development of CVD.

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