For patients who are posthospitalization and on warfarin therapy, one key component is the proper management of warfarin therapy. This descriptive study was conducted using a telephone survey to determine what level of knowledge exists regarding management of warfarin among patients back at home. Analysis of data collection results provides recommendations for evidenced-based practices for the home health clinician, which may improve patient outcomes. Basic knowledge of food and medication interactions can make a significant impact on reduction of adverse events of bleeding or clot formation. An understanding of the therapeutic level of warfarin obtained from lab tests could be of greater value.