Cerebrospinal Fluid Dynamics and Relation with Blood Flow: A Magnetic Resonance Study with Semiautomated Cerebrospinal Fluid Segmentation


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Abstract

Balédent O, Henry-Feugeas MC, Idy-Peretti I. Cerebrospinal fluid dynamics and relation with blood flow: A magnetic resonance study with semiautomated cerebrospinal fluid segmentation. Invest Radiol 2001;37:368–377.rationale and objectives. To investigate and measure temporal and amplitude aspects of blood and cerebrospinal fluid (CSF) flow waveform relations.methods.A cine phase-contrast magnetic resonance imaging pulse sequence was used to measure blood and CSF flow in 16 healthy subjects aged 27 ± 4 years. A semiautomated segmentation algorithm was developed to study CSF flow.results.Standard deviations of the aqueductal and cervical flow measurements carried out by five observers were 1% and 4%, respectively. The peak systolic arterial flow was 1087 ± 169 mL/min, and the peak cervical CSF flush (173 ± 59 mL/min) occurred at 5% ± 3% of the cardiac cycle after the internal carotid systolic peak flow. Peak aqueductal flush flow (13 ± 5 mL/min) occurred at 21% ± 7% of the cardiac cycle after the internal carotid systolic peak flow.conclusions.The CSF segmentation algorithm is reproducible. Brain expansion was quickly regulated by a major extracerebral CSF flush flow, whereas ventricular CSF made only a very small contribution.

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