Comparison of Multiple Sclerosis Lesions at 1.5 and 3.0 Tesla

    loading  Checking for direct PDF access through Ovid

Abstract

Objective

To evaluate the relative sensitivity of MR scanning for multiple sclerosis (MS) at 1.5 Tesla (T) and 3.0 T using identical acquisition conditions, as is typical of multicenter clinical trials.

Methods

Twenty-five subjects with MS were scanned at 1.5 T and 3.0 T using fast spin echo, and T1-weighted SPGR with and without gadolinium contrast injections. Image data, blinded to field strength, were analyzed using automated segmentation and lesion counting.

Results

Relative to scanning at 1.5 T, the 3.0 T scans showed a 21% increase in the number of detected contrast enhancing lesions, a 30% increase in enhancing lesion volume and a 10% increase in total lesion volume.

Discussion

The improved detection ability using high-field MR imaging is prominent even when sequence parameters are optimized around the midfield units. Multicenter trials using both 1.5 T and 3.0 T instruments may be affected by these sensitivity differences.

Related Topics

    loading  Loading Related Articles