DOI: 10.2106/JBJS.I.00727

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PMID: 20360526

Issn Print: 0021-9355

Publication Date: 2010/04/01


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Monostotic Fibrous Dysplasia of the Spine: A Report of Seven Cases

Andrew J. Schoenfeld; Stephanie A. Koplin; Ron Garcia; Francis J. Hornicek; Henry J. Mankin; Kevin A. Raskin; Dempsey Springfield; Andrew E. Rosenberg; Joseph H. Schwab

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Author Information: Departments of Orthopaedic Surgery (A.J.S., R.G., F.J.H., H.J.M., K.A.R., D.S., and J.H.S.) and Pathology, WRN 225 (S.A.K. and A.E.R.), Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114

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Excerpt

Monostotic fibrous dysplasia of the spine is rare, with the cases of fewer than thirty-five patients discussed in the literature. Dahlin and Unni reviewed the cases of 418 patients with monostotic fibrous dysplasia and noted six (1.4%) involving the spine1. In a series reported by Harris et al., one patient with spine involvement was noted in a total of thirteen patients with monostotic fibrous dysplasia2. Most reports have described the case of a single patient with minimal to no follow-up1-23. As a result, the natural history and ideal treatment for this condition remain poorly understood. For example, the prevalence of scoliosis in patients with polyostotic fibrous dysplasia has been found to be up to 40%24, whereas scoliosis in monostotic fibrous dysplasia appears to be quite rare25. The reported treatment of monostotic fibrous dysplasia in the spine also has varied widely, from surgical resection4,5,7,9-19 to biopsy and observation2,21.

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