Aloe Vera Gel Hindered Wound Healing of Experimental Second-Degree Burns: A Quantitative Controlled Study

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In the present study, Aloe vera gel (AVG) was applied to experimental second-degree burns in guinea pigs, and its effects on epithelialization, wound contraction, newly formed granulation tissue, and regeneration of hair follicles was compared with that effected by 1% silver sulfadiazine cream (AgSD).Epithelialization (96mean ± SEM) on postburn day 8, 16, and 24 of the AVG-treated wounds was 38.72% ± 2.7196, 60.34% ± 3.28%, and 92.46% ± 2.26%, respectively, while that of the AgSD-treated burns was 53.35% ± 2.65%, 94.84% ± 2.65%, and 100%, respectively (P < .001). Contraction of the AVG-wounds was significantly higher than that of the AgSD-treated burns during 24 days of the study (P < .001). The thickness of the newly formed granulation tissue was higher in the AVG-treated wounds (P < .001), while the hair follicles count was significantly lower (P < .001) compared with the AgSD-treated burns.It is concluded that this preparation of Aloe vera gel hindered the healing process of the present burn wound model when compared with 1% silver sulfadiazine cream.

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