Alterations in Monoamine Receptors in the Brain of Suicide Victims


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Abstract

Suicide has been linked to alterations in the serotonergic and noradrenergic systems. Using in vitro quantitative receptor autoradiography, we compared the binding of 125I-lysergic acid diethylamide (5-hydroxytryptamine-2 sites) and 125I-pindolol (β-adrenergic sites) with slide-mounted sections from the prefrontal and the temporal cortex of a group of suicide victims, matched to control specimens on postmortem interval, age, sex, and race. A specific laminar distribution of 5-hydroxytryptamine-2 binding was found in both groups, with layers III and IV having the highest level of binding, but β-adrenergic binding did not differ across cortical layers. Binding to both 125I-lysergic acid diethylamide and 125I-pindolol was increased in the prefrontal cortex of the suicide victims, whereas only β-adrenergic binding was increased in the temporal cortex of the suicide group.

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