Cerebral MR and CT Imaging in Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy

Abstract

Abstract

Cerebral magnetic resonance (MR) and CT imaging of two patients with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLO-SL) showed widespread progressive central and cortical atrophy. Computed tomography revealed calcifications in the area of the caudate nuclei and putamina in both patients. A reduced volume of brain white matter with deep cortical sulci was the most striking MR finding. Rather short relaxation times in periventricular areas adjacent to ventricular bodies were also observed.