In a population-based prospective study, no association between high blood pressure and mortality after age 85 years


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Abstract

ObjectiveTo study the impact of a history of hypertension and current blood pressure on mortality in the oldest old.DesignAn observational population-based cohort study.SettingCommunity city of Leiden, The Netherlands.ParticipantsFive hundred and ninety-nine inhabitants of the birth-cohort 1912–1914 were enrolled on their 85th birthday. There were no selection criteria related to health or demographic characteristics.InterventionsThe mean follow-up was 4.2 years. Medical histories were obtained from general practitioners. Medication histories were obtained from the participant's pharmacist. Blood pressure was measured twice at baseline.Main outcome measuresAll cause and cardiovascular mortality.ResultsFive hundred and seventy-one participants were included, 39.2% had a history of hypertension. During follow-up 290 participants died, 119 due to cardiovascular causes. Compared to participants without a history of hypertension, those with a history of hypertension had increased mortality from cardiovascular causes [relative risk (RR) 1.60, confidence interval (CI) 1.06–2.40] but equal mortality from all causes (RR 1.19, CI 0.91–1.55). High blood pressure at baseline (age 85) was not a risk factor for mortality. Baseline blood pressure values below 140/70 mmHg (n = 48) were associated with excess mortality, predominantly in participants with a history of hypertension.ConclusionIn the oldest old, high blood pressure is not a risk factor for mortality, irrespective of a history of hypertension. Blood pressure values below 140/70 mmHg are associated with excess mortality.

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