DOI: 10.1097/01.hjh.0000469868.51756.1f
,
Issn Print: 0263-6352
Publication Date: 2015/06/01
Facebook
Twitter
LinkedIn
Email
 |
Checking for direct PDF access through Ovid | |
Abstract
Background:Women develop coronary atherosclerosis 10 years later than men and the occurrence of coronary calcification tracks with this later onset of coronary artery disease. These gender differences in occurrence of coronary calcium support the association of coronary artery calcification (CAC) with coronary atherosclerosis and underline the importance of age- and gender-specific reference points for CAC scoring. CAC is a predictor of future cardiovascular events, however, the gender differences of the predictors of coronary calcification has remained unclear.
Methods:This retrospective study aims to evaluate the gender differences of predicting CAC, which carried out in consecutive 1505 male and 1481 female outpatients who had been evaluated for the presence of coronary artery calcification from July 2010 to February 2011 at our institution, with mean age of 49 in males and mean age of 51in females. Blood pressure, anthropometrics parameters and CVRF questionnaire forms were collected, andthe CAC Scores wereobtained by 64-slice DSCT scan.
Results:The bivariate analysis of CVRFs and CAC found age(r = 0.529, p < 0.001), hypertension(r = 0.328, p < 0.001), history of DM(r = 0.181, p < 0.001) and lack of exercise (r = 0.133, p < 0.001) had the strongest correlation with CAC score in male group, while age (r = 0.555, p < 0.001) and hypertension (r = 0.326, p < 0.001), history of dyslipidemia (r = 0.210, p < 0.001) and obesity (r = 0.191, p < 0.001)had the strongest correlation with CAC scorein female group. The further multivariate analysis of CVRFs to CAC presence in female found the highest odds ratio was age (OR = 6.493, 95%CI:4.676-9.015), followed by hypertension OR = 2.142, 95%CI:1.494–3.070).
Conclusions:There were difference strength of CVRFs for severity of coronary calcification prediction between gender. Age, hypertension, history of dyslipidemia and obesity were stronger predictors consecutively in women. While in men; age, hypertension, history of diabetes and lack of exercise were the stronger ones.
