MPS 06-05 FAMILY HISTORY OF CARDIOVASCULAR DISEASE AND AUTONOMIC REGULATION OF CIRCULATION IN MIGRAINEURS WITH AND WITHOUT CONCOMITANT HYPERTENSION

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Abstract

Objective:

It has been reported that migraine patients are at greater risk of cardiovascular complications. We hypothesize that this may be caused by features of the autonomous regulation of blood flow and/or heredity of the cardiovascular disease (HCD). The purpose of the study is exploration of the links between the heredity of cardiovascular diseases and autonomic regulation in migraineurs with and without concomitant arterial hypertension.

Design and Method:

103 patients with migraine (mean age 34.4 ± 10 y) including 27 patients with (M+H) and 76 patients without (M-H) hypertension have been examined. The control group consisted of 88 matched healthy volunteers. All participants were asked to fill up questionnaires concerning medical history of the closest relatives. Autonomic regulation of circulation was experimentally assessed by six different tests, which included tilt-table test (TT), a deep breathing (DB) and Valsalva Maneuver with estimation of the Valsalva index (VI) and mean-blood-pressure increment during the second phase (IBPVM), handgrip test (HG), cold-stress vasoconstriction (CSV), and arterial baroreflex (BRS).

Results:

We found that BRS was lower in the M+H group whereas no difference was found between M-H and control group. There were no differences in VI and DP among the groups. Moreover, dynamics of diastolic blood pressure during TT was higher in М+H group compare to both M-H and control group. However, three vasomotor parameters (IBPVM, HG, and CSV) were higher in both M+H and M-H groups compared to the control group. In addition, HCD was seen frequently in both migraine groups compare to the control group.

Conclusions:

Concomitant arterial hypertension in migraineurs is associated with additional reduction of BRS and orthostatic hypertension, but both heredity of cardiovascular disease and increased neurogenic vasomotor reactivity are more frequent in migraine patients regardless of hypertension.

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