DOI: 10.1097/01.hjh.0000501062.12923.d5
,
Issn Print: 0263-6352
Publication Date: 2016/09/01
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Abstract
Objective:Recently several studies reported that anti-hypertensive drugs were associated with development of new-onset diabetes mellitus (NODM). However, data on the relationship between detailed prescription types and long-term incidence of NODM are still limited, particularly in Asian patients (pts).
Design and Method:A total of 2,042 consecutive hypertension pts were enrolled with the exclusion of diabetic pts. Pts were divided into two groups according to the prescription); 1) the calcium channel blockers (CCBs, n = 1,461) and angiotensin receptor blockers (ARBs, n = 565). NODM was defined as having a fasting blood glucose ≥ 126 mg/dL or HbA1c ≥ 6.5%. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Primary end-point was NODM and in addition, individual and composite major adverse cerebro-cardiac events (MACCE) were compared between the two groups up to 5 years.
Results:After PSM analysis, two propensity-matched groups (565 pairs, n = 1030, C-statistic = 0.695) were generated and the baseline characteristics were balanced. Up to 5 years, there was no significant difference in the incidence of NODM, total death, myocardial infarction, stroke, percutaneous coronary intervention (PCI) and composite MACCE between the two groups.
Conclusions:In our study, there were no differences in the incidence of NODM and major clinical outcomes between the CCB group and the ARB group.
