The Journal of Nervous and Mental Disease. 197(11):865-868, NOVEMBER 2009

DOI: 10.1097/NMD.0b013e3181be7422

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PMID: 19996727

Issn Print: 0022-3018

Publication Date: November 2009


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A Preliminary Controlled Trial of Cognitive Behavioral Therapy in Clozapine-Resistant Schizophrenia

Eliza de Paiva Barretto;Monica Kayo;Belquiz Avrichir;Antonio Sa;Maria das Camargo;Isabel Napolitano;Fabiano Nery;Jony Pinto;Silvia Bannwart;Silvia Scemes;Elaine Di Sarno;Helio Elkis;

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Abstract

The use of cognitive-behavior therapy (CBT) in addition to antipsychotic regimen to treat persistent psychotic symptoms of schizophrenia is growing. The aim of this study was to compare the efficacy of CBT to a befriending (BF) control group in patients with schizophrenia who are refractory to clozapine. Twenty-one patients completed the 21-week trial. In comparison with the control group, the CBT group showed a significant improvement in the General Psychopathology and total score of the Positive and Negative Syndrome Scale, as well as an improvement of Quality of Life scale. The improvement in psychopathology persisted at 6-month follow-up assessment.

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