Comparison of Healing Process in Open Osteotomy Model and Closed Fracture Model

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Abstract

Objective:

Comparison of the healing process in open osteotomy and closed fracture models that were used to study fracture healing.

Design:

Randomized, prospective study in experimental animals, with a recovery duration of two and four weeks.

Setting:

Unrestricted cage activity with weight bearing as tolerated.

Animals:

Thirty-four skeletally mature, female New Zealand White rabbits.

Interventions:

Closed fractures and open osteotomies of the tibial diaphysis were reduced and immobilized with four-pin, double-bar external fixators.

Main Outcome Measurements:

Callus circumference was measured with a tape measure, bridging callus was assessed on biplane radiographs and evaluated histologically, and torsional stiffness and maximum torque were measured.

Results:

Periosteum damage was more severe and hematoma formation was smaller in the osteotomy model, resulting in a delay in biological healing and restoration of the biomechanical properties.

Conclusions:

Investigators should consider the difference between the closed fracture and open osteotomy models when selecting an animal model to investigate fracture healing.

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