DOI: 10.1097/BOT.0b013e31819194f1
,
Issn Print: 0890-5339
Publication Date: 2009/02/01
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Excerpt
As far as the end points are concerned, the authors chose embolism, histology, and the coagulatory response, just as in previous models. It would have been interesting to measure inflammatory changes as well, but this option is not available in a sheep model. Also, the pulmonary permeability changes can be measured more precisely, if Staub's model (isolation of pulmonary lymph) is selected and the pulmonary lymph node is cannulated.
Given these considerations regarding the selection of the animal model, the clinical relevance of the results obtained has to be selected carefully. In view of a greater embolic load in bilateral nailings, does this mean that the intramedullary fixation is harmful? Or does it mean that it is safe given the fact that other parameters were unchanged? It would seem as if the embolic load did not cause additional harm because none of the other physiologic parameters were altered. However, it is of note that none of these animals were in a critical condition because none of them showed any sign of acidosis. As discussed by the authors, additional trauma might sharpen the results obtained. In the current model, the bilateral nailing procedures did not cause any harm. The authors discuss that additional injuries may be required to cause a more substantial physiologic response by the trauma. Future studies may be helpful in this respect.
