PMID: 10067740
Issn Print: 0277-2116
Publication Date: 1999/03/01
Cyclosporine for Rectoperineal Fistula in a Human Immunodeficiency Virus-Infected Child
Désirée Caselli; Anna Maccabruni; Giampiero Beluffi; Lorenzo Minoli
Excerpt
Inflammatory conditions of the anal-rectal area were reported in a significant proportion of human immunodeficiency virus (HIV)-positive adults from a surgical survey (1). Two simultaneous reports independently suggest that acquired rectovaginal fistula may be an unexpected complication in HIV-infected infant girls (2,3). Of note, both reports came from African countries, but at least one European case is reported (4). Acquired rectoperineal fistulas may also complicate the course of chronic inflammatory bowel disease in HIV-negative patients. Surgery and immunosuppression therapy have been used for its treatment with nonuniform results (5). Cyclosporine has been successfully used in children with Crohn's disease, ulcerative colitis, or chronic granulomatous disease (6-12) and for Crohn's-associated fistulas (13).
We report the successful treatment with cyclosporine of a rectoperineal fistula in an HIV-infected male child.
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