Issn Print: 0277-2116

Publication Date: 2004/06/01


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P0452 CELIAC DISEASE PREVALENCE IN BLOOD DONNORS AND CLINICAL ASPECTS OF THE PATIENTS IN RIBEIRÃO PRETO-BRAZIL

L. C. Galvão; S. B. C. Melo; M. M. Fernandes; L. Peres; L. A. Troncon; E. V. Melo

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Author Information: Department of Pediatrics,

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Introduction: Celiac Disease (CD) is a disorder underdiag-nosed in medical practice. With the development of serologic exams, screening studies have shown a new profile of prevalence in the World. In Brazil, few studies are avaiable about the prevalence of CD(1). The objective of the present study was to determine CD prevalence among blood donnors in Ribeirão Preto- Brazil.
Methods: We collected 3000 blood samples from donors of Hemocentro (1500 males end 1500 females, aged 18 to 45 years). The samples were tested for the presence of anti-tissue transglutaminase antibodies(anti-tTG)by ELISA and anti-tTG positive(+) samples were tested for the anti-endomysium antibodies (EMA) by indirect immunofluorescence. Individulas positive to both tests were submitted to clinical evaluation and to an intestinal biopsy. The fragment obtained was analysed according to Marsh criteria (2). Statistical test: Fisher (p<0.05).
Results: The mean age was 29.7 +/− 2.9 years. Sample analysis revelead low anti-tTG positivity in 13 cases, all of then EMA- and medium-high anti-tTG+ in 24, 9 of which were EMA-and 15 EMA+. Of the 13 biopsies performed, 2 were normal (Marsh 0)and 11 abnormal (1 Marsh IV, 4 type III, 2 type II and 4 type I). Two men did not permit the biopsy. The prevalence found was 1:276 (0.36% with 95%IC 0.15 to 0.58). Of the 11 patients, 10 were females. Gastrintestinal symptoms were reported by 9 patients. A family history of gastrointestinal neoplasia was reported by 4 subjects and of epilepsy by 3 patients; these data were statistically different from the non-celiac individuals (p=0.002 and 0.07, respectively). All of the first-degree relatives were Brazilians (no different from the non-celiac group)and of the second-degree relatives, 5 were Brazilians, 3 Italians and 2 Spanish (different from the non-celiac group p=0.01).
Conclusion: 1-These results demonstrate a CD prevalence of 1:275 in a supposedly healthy population, similar to the European prevalence. 2- This prevalence is higher than that of the similar study in Brazil (1:687), probably due to the different ethnic origins of the populations in the two regions studied. 3-The frequency was higher among females and among individuals of European ancestry. 4-Subjects with CD showed a higher frequency of a familiar history of gastrintestinal neoplasia end epilepsy.

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