Issn Print: 0277-2116
Publication Date: 2006/10/01
HELICOBACTER PYLORI EXTRACT INDUCES REACTIVE OXYGEN SPECIES PRODUCTION IN MOUSE GASTRIC MUCOSAL CELLS
Jonathan M. Gisser; Steven J. Czinn; Reinaldo Garcia-Naveiro; Thomas G. Blanchard
+ Author Information
Author Information: Pediatrics, Case Western Reserve University-Rainbow Babies and Children's Hospital, Cleveland, OH;
Excerpt
The mechanism that leads to Helicobacter pylori (H. pylori)-associated gastritis is unclear. We hypothesize that gastric surface mucous (GSM) cell NADPH-oxidase, like its phagocyte counterpart, contributes to inflammation by producing reactive oxygen species (ROS). Detecting NADPH-oxidase activity in gastric mucosa has been challenging. We utilized non-transfected immortalized GSM cells to determine whether H. pylori bacterial components can elicit an NADPH-oxidase-catalyzed oxidative burst.
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