Issn Print: 0277-2116
Publication Date: 2006/10/01
PATHOLOGIC ZYMOGEN ACTIVATION IN PANCREATITIS IS DEPENDENT UPON CALCINEURIN ACTIVATION
Sohail Z. Husain; Ahsan U. Shah; Wayne M. Grant
Excerpt
The premature activation of digestive proenzymes (zymogens) within the pancreatic acinar cell is an early and critical event during acute pancreatitis. Our previous studies demonstrate that this activation requires a distinct pathologic rise in cytosolic calcium. However, the mechanism of this calcium effect remains unclear. An important target of calcium in acinar cells is the calcium-calmodulin dependent phosphatase calcineurin (PP2B). While PP2B appears to have a role in regulated amylase secretion, its effect on zymogen activation is unknown.
Facebook
Twitter
LinkedIn
Email
