Helicobacter pylori and Iron-deficiency Anemia in Adolescents in Brazil

    loading  Checking for direct PDF access through Ovid



The aim of the study was to evaluate the association between Helicobacter pylori infection and iron deficiency (ID) in adolescents attending a public school.

Patients and Methods:

From March to June 2001, a cross-sectional study was conducted among adolescents (10–16 years) enrolled in a single public school in São Paulo, Brazil. Of 400 eligible students, 195 agreed to participate, but 1 was excluded due to sickle cell disease. A blood sample was collected from each subject to measure hemoglobin and ferritin. H pylori status was investigated with the 13C-urea breath test. All of the subjects with either anemia or ID were given iron therapy.


H pylori prevalence was 40.7% (79/194), being higher in male subjects (45/90 vs 34/104, P = 0.014). There was no relation between infection and nutritional status. Abnormally low serum ferritin was observed in 12 subjects, half of whom were positive for H pylori (odds ratio [OR] 1.49, 95% confidence interval [CI] 0.38–5.81). The median serum ferritin was 33.6 ng/mL (interquartile range 23.9–50.9) in infected subjects and 35.1 ng/mL (interquartile range 23.7–53.9) in uninfected subjects. Anemia was detected in 2% (4/194) of the students, half of whom were infected (OR 1.47, 95% CI 0.1–20.6). The mean hemoglobin value in infected subjects was 13.83 g/dL ± 1.02 versus 14 g/dL ± 1.06 in uninfected subjects.


The study was not able to find a relation between H pylori infection and ID or anemia.

Related Topics

    loading  Loading Related Articles